JPD Blog

In this section of the JPD blog, Jon Palfreman contributes news of interest to the PD research community, in the form of short opinion items and regular blog posts.

 

Glimmers of Hope

In November 1987, Lund neuroscientists grafted fetal dopamine neurons into the brain of a 47-year old PD patient, launching a hopeful new era of neural grafting aimed at reversing the symptoms of PD.

IOS Press publishes a new edition of The Case of the Frozen Addicts

In 1985, I produced a documentary for the PBS series NOVA, entitled “The Case of the Frozen Addicts”. The film told the story of six young California drug abusers mysteriously struck with the symptoms of Parkinson’s disease, a neurodegenerative condition that normally affects the elderly. Bill Langston, then an unknown clinician at the San Jose Valley Medical Center, discovered the unlucky individuals languishing in psych wards and jail cells and had temporarily reversed their symptoms with the drug L-dopa.

Letter from Stockholm: Disruption Ahead!

One of the most interesting events at the 18th International Congress of Parkinson’s Disease and Movement Disorders in Stockholm was a dinner hosted by the Kinetics Foundation.

Letter from Stockholm: Learning From Our Failures

The hunt for so-called disease-modifying interventions for Parkinson’s disease has not been going well of late. In Stockholm this week at the 18th International Congress of Parkinson’s Disease and Movement Disorders, some of the world’s leading researchers gave their differing analyses of what lessons should be learned from the set backs.

Optimal Care

The current issue of the Journal of Parkinson’s Disease includes a new feature, “How I examine my patient”, a section designed to help improve the clinical skills of physicians, allied health professionals, and other professionals involved in the care of patien

Under My Skin

Many PD patients who take multiple carbidopa-levodopa pills orally every day experience sharp fluctuations in levodopa levels and suffer associated motor complications (e.g. intermittent "off" and "on" periods). Israeli-based NeuroDerm Ltd. has just reported encouraging news about its novel platform that seeks to minimize this problem by delivering liquid carbidopa-levodopa continuously over 24 hours.

Profile: Patrik Brundin

Swedish neuroscientist Patrik Brundin keeps a picture of his father on his office wall as a reminder of why he became a Parkinson’s disease researcher. In 1974, when the Brundin family lived in Darlington, in the north of England, a local neurologist Dr Saunders diagnosed Patrik’s father, Bertil, with Parkinson's disease. Bertil Brundin –-an executive for a Swedish lawnmower company called Flymo–- was put on the just released medication, L-dopa. Patrik remembers his mother asking the neurologist “would it arrest the disease”? To which Dr.

Profile: J. William Langston

Meet Bill Langston, a giant of neuroscience. A major researcher who’s co-authored some 360 peer-reviewed articles. The winner of numerous awards, including the Sarah M. Poiley Award from the New York Academy of Sciences, the James Parkinson 30th Anniversary Award from the Parkinson’s Disease Foundation, and the Movement Disorders Research Award from the American Academy of Neurology.

Pricey Placebos

The placebo effect is a puzzling concept to get your head around. The idea that an essentially inert intervention — like a sugar pill, a saline injection, or a sham operation — can produce therapeutic benefit seems to defy common sense. But it’s very real.

24 June 2015

What Is the Role of the Gut Microbiome in Developing Parkinson’s Disease?

Gut Microbiota Interactions Chart

In recent years, an important Parkinson’s disease (PD) research focus has been on gut-related pathology, pathophysiology, and symptoms. Gastrointestinal dysfunction, in particular constipation, affects up to 80% of PD patients and idiopathic constipation is one of the strongest risk-factors for PD. Lifestyle factors such as smoking and coffee consumption, as well as blood urate levels, have been associated with a decreased PD risk.

Old Contact

 

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Aims and Scope

The Journal of Parkinson’s Disease is dedicated to providing an open forum for original research in basic science, translational research and clinical medicine that will expedite our fundamental understanding and improve treatment of Parkinson’s disease. The journal is international and multidisciplinary and aims to promote progress in the epidemiology, etiology, genetics, molecular correlates, pathogenesis, pharmacology, psychology, diagnosis and treatment of Parkinson’s disease. It will publish research reports, reviews, short communications, and letters-to-the-editor and offers very rapid publication and affordable open access.

Editorial Board

Editors-in-Chief

Bas Bloem, MD, PhD, FRCPE
Center of Expertise for Parkinson & Movement Disorders
Radboud University Medical Centre
Nijmegen, the Netherlands
Email: bas.bloem@iospress.com

Lorraine V. Kalia, MD, PhD, FRCPC
Division of Neurology, Department of Medicine
University of Toronto
Toronto, ON, Canada
Email: l.kalia@iospress.com

Editors-in-Chief Emeritus

Patrik Brundin, MD, PhD
Roche, Grand Rapids, MI, USA

J. William Langston, MD
Stanford University, Palo Alto, CA, USA

Associate Editor for Reviews

Rodolfo Savica
Department of Neurology, Mayo Clinic, Rochester, USA

Tiago Fleming Outeiro
Georg-August-Universität Göttingen, Göttingen, Germany

Associate Editors

Roy N. Alcalay
Columbia University, New York, USA

Roger Barker
University of Cambridge, Cambridge, United Kingdom

Erwan Bezard
University of Bordeaux, Bordeaux, France

Roongroj Bhidayasiri
Chulalongkorn University, Bangkok, Thailand

Camille B. Carroll
University of Plymouth, Plymouth, United Kingdom

Mark R. Cookson
NIH, Bethesda, USA 

Kelly D. Foote
University of Florida/Fixel Institute for Neurological Diseases, Gainesville, USA

Ziv Gan-Or
Montreal Neurological Institute, McGill University, Montreal, Canada

Glenda Halliday
The University of Sydney, Sydney, Australia

Nobutaka Hattori
Juntendo University School of Medicine, Tokyo, Japan

Jeffrey H. Kordower
Rush University, Chicago, USA

Tilo Kunath
University of Edinburgh, Edinburgh, UK

Matthew J. Lavoie
The University of Florida College of Medicine, Florida, USA

Simon J.G. Lewis
Macquarie University , Sydney, NSW, Australia

Tim Lynch
Dublin Neurological Institute at the Mater Hospital, University College Dublin, Dublin, Ireland

Anat Mirelman
Department of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Caroline Moreau
Expert Center for Parkinson's Disease, University Hospital of Lille, Lille, France

Alice Nieuwboer
Catholic University Leuven, Leuven, Belgium

Alastair Noyce
Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United Kingdom

Laurie H. Sanders
Department of Neurology, Duke University School of Medicine, Durham, NC, USA

Rick Schuurman
Amsterdam University Medical Centers, Amsterdam, the Netherlands

Antonio Strafella
Krembil Research Institute, Toronto, ON, Canada

Eng King Tan
Duke NUS Graduate Medical School, Singapore, Singapore

Aleksandar Videnovic
Massachusetts General Hospital, Harvard Medical School, Boston, USA

Nienke M. de Vries
Center of Expertise for Parkinson and Movement Disorders, Radboud University Medical Centre, Nijmegen, the Netherlands

Doris Wang
Neurological Surgery, School of Medicine, University of California, San Francisco, USA

Amanda L. Woerman
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA

Cornelis Blauwendraat, PhD
Integrative Neurogenomics Unit, National Institute on Aging, Bethesda, MD, USA 

Suneil Kalia, MD, PhD
Department of Surgery, University of Toronto, Toronto, ON, Canada

Associate Editors of Clinical Trials Highlights

Kevin McFarthing
Parkinson’s Advocate, Innovation Fixer Ltd, Oxford, UK

Tanya Simuni
Parkinson's Disease and Movement Disorders Center,
Northwestern University Feinberg School of Medicine, Chicago, USA

Associate Editor of Hidden Gems

Peter A. LeWitt
Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA

Associate Editor for Statistics

Jeremy Syrjanen
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, USA

Managing Editor
Beth Kumar
Case Western Reserve University, Cleveland, USA
Email: jpd@iospress.com

Editorial Board
Dag Aarsland
University of Stavanger, Stavanger, Norway

Asa Abeliovich
Columbia University College of Physicians & Surgeons, New York, USA

Yves Agid
Institut du Cerveau et de la Moelle épinière, Paris, France

Alberto Albanese
National Neurological Hospital Carlo Besta, Milan, Italy

Ernest Arenas
Karolinska Institute, Stockholm, Sweden

Alberto Ascherio
Harvard School of Public Health, Boston, USA

Alim Benabid
University of Grenoble, Grenoble, France

Daniela Berg
Christian-Albrechts-Universität zu Kiel, Kiel, Germany

Hagai Bergman
The Hebrew University, Jerusalem, Israel

Erwan Bezard
University of Bordeaux, Bordeaux, France

Anders Björklund
Lund University, Lund, Sweden

Vincenzo Bonifati
Erasmus MC, Rotterdam, the Netherlands

Heiko Braak
University of Ulm, Ulm, Germany

Jose Bras
University College London, London, UK

Alexis Brice 
Pierre and Marie Curie University, Paris, France

Helen Bronte-Stewart
Stanford University, Palo Alto, USA

David J. Brooks
Hammersmith Hospital, London, United Kingdom

Paolo Calabresi
Policlinico Gemelli, Catholic University, Rome, Italy

M. Angela Cenci Nilsson
Lund University, Lund, Sweden

Piu Chan
Beijing Institute of Geriatrics, Beijing, China

K. Ray Chaudhuri
Kings College Hospital, London, United Kingdom

Marie Francoise Chesselet
University of California Los Angeles, Los Angeles, USA

Cynthia Comella
Rush University Medical Center, Chicago, USA

Ted M. Dawson
Johns Hopkins University School of Medicine, Baltimore, USA 

Valina L. Dawson
Johns Hopkins University School of Medicine, Baltimore, USA

Benjamin Dehay
University of Bordeaux, Bordeaux, France

Steve DeWitte
Connecticut Advocates for Parkinson's, New Preston Marble Dale, USA

Dennis Dickson
Mayo Clinic, Scottsdale, USA

Robert H. Edwards
University of California San Francisco, San Francisco, USA 

David Eidelberg
The Feinstein Institute for Medical Research, New York, USA

Omar M. El-Agnaf
United Arab Emirates University, Al-Ain, United Arab Emirates

Alberto Espay
University of Cincinatti, Cincinatti, USA

Stanley Fahn
Columbia University College of Physicians & Surgeons, New York, USA

Matt Farrer
University of British Columbia, Vancouver, Canada

Howard Federoff
Georgetown University, Washington, USA

Joaquim Ferreira
Hospital de Santa Maria, Lisbon, Portugal

Tom Foltynie
University College London, London, UK

Thomas Gasser
University of Tuebingen, Tuebingen, Germany

Larry Gifford
PD Avengers, Vancouver, BC, Canada

Nir Giladi
Tel Aviv University, Tel Aviv, Israel

Ann M. Graybiel
MIT, Cambridge, USA

J. Timothy Greenamyre
University of Pittsburgh, Pittsburgh, USA

James G. Greene
Emory University, Atlanta, USA

Rita Guerreiro
University College London, London, UK

Mark Hallett
NIH, Bethesda, USA

John Hardy
University College London, London, United Kingdom

Etienne C. Hirsch
Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, Paris, France

Joseph Jankovic
Baylor College of Medicine, Houston, USA 

Christine Klein
University of Lübeck, Lübeck, Germany

Han Seok Ko
Johns Hopkins, Baltimore, USA

Amos D. Korczyn
Tel Aviv University, Ramat Aviv, Israel

Dimitri Krainc
Northwestern University, Chicago, USA

Emma L. Lane
Cardiff University, Cardiff, Wales, UK

Seung-Jae Lee
Konkuk University, Seoul, South Korea

Virginia Lee
University of Pennsylvania School of Medicine, Philadelphia, USA

Peter A. LeWitt
Wayne State University, Detroit, USA
Henry Ford Hospital, Detroit, USA

Olle Lindvall
Lund University, Lund, Sweden

Andres Lozano
University of Toronto, Toronto, Canada 

Laura Marsh
Baylor College of Medicine, Houston, USA

Ian Martin
Oregon Health & Science University, Portland, USA

Soania Mathur
Designing a Cure Inc., Toronto, Canada

Mark P. Mattson
Johns Hopkins University School of Medicine, Baltimore, USA

Wassilios Meissner
University Hospital Bordeaux, Bordeaux, France

Darren Moore
Van Andel Institute, Grand Rapids, USA

Robert Nussbaum
University of California San Francisco, San Francisco, USA

Tiago Outeiro
University Medical Center Göttingen, Göttingen, Germany

Jon Palfreman
University of Oregon, Eugene, USA

Ronald F. Pfeiffer
Oregon Health and Sciences University, Portland, USA

Serge Przedborski
Columbia University Medical Center, New York, USA

Heinz Reichmann
University of Dresden, Dresden, Germany

Tamas Revesz
University College London, London, United Kingdom

Olaf Riess
University of Tuebingen, Tuebingen, Germany

Trevor Robbins
University of Cambridge, Cambridge, United Kingdom

Marina Romero Ramos
Aarhus University, Aarhus, Denmark

Anthony Schapira
University College London, London, United Kingdom

Sonja Scholz
NIH, Bethesda, USA

Jie Shen
Harvard Medical School, Boston, USA

Todd Sherer
Michael J. Fox Foundation, New York, USA

Ira Shoulson
Georgetown University, Washington, USA

Andrew Singleton
NIH, Bethesda, USA

Richard Smeyne
Thomas Jefferson University, Philadelphia, USA

Yoland Smith
Emory University, Atlanta, USA

Jon Stamford
Parkinson's Movement & The Cure Parkinson's Trust, London, United Kingdom

David G. Standaert
University of Alabama at Birmingham, Birmingham, USA

Leonidas Stefanis
University of Athens Medical School, Athens, Greece

Dennis Steindler
University of Florida, Gainesville, USA

Benjamin Stecher
tmrwedition.com, Toronto, Canada

Fabrizio Stocchi
IRCCS San Raffaele, Rome, Italy

A. Jon Stoessl
University of British Columbia, Vancouver, Canada

David L Sulzer
Columbia University, New York, USA

James Dalton Surmeier
Northwestern University, Chicago, USA

Michele Tagliati
Cedars-Sinai Medical Center, Los Angeles, USA

Jun Takahashi
Kyoto University, Kyoto, Japan

Caroline M. Tanner
The Parkinson's Institute and Clinical Center, Sunnyvale, USA

Malú G Tansey
University of Florida College of Medicine, Gainesville, USA

Bobby Thomas
Medical University of South Carolina, Charleston, USA

Eduardo Tolosa
University of Barcelona, Barcelona, Spain

Jens Volkmann
Universitätsklinikum Wurzburg, Wurzburg, Germany

Laura Volpicelli-Daley
The University of Alabama at Birmingham, Birmingham, USA

Daniel Weintraub
University of Pennsylvania, Philadelphia, USA

Nick Wood
University College London, London, United Kingdom 

Zhenyu Yue
Icahn School of Medicine at Mount Sinai, New York, USA

Hannington Kabugo
Parkinson's si Buko Uganda, Kampala, Uganda

David J Blacker
Perron Institute for neurological and translational science, Nedlands, Australia

Founding Editors from the Journal of Alzheimer’s Disease
George Perry
University of Texas at San Antonio, San Antonio, USA

Mark A. Smith†
Case Western Reserve University, Cleveland, USA

About the Journal

The Journal of Parkinson's Disease  (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer's Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.

Publication
From 2022, the journal publishes eight issues per annual volume; prior to this it was four issues per year. From 2023 the journal will proceed as an open access publication, where all articles from the 2023 volume onwards will be openly available.

Impact Factor
JPD has a Journal Impact Factor of 5.2, and a CiteScore of 6.9 (2023 Journal Citation Reports, source: Clarivate, 2023).

Abstracted/Indexed in
Chemical Abstracts Service (CAS), Embase, Journal Citation Reports/Science Edition, MEDLINE, PsycINFO, PubsHub, Science Citation Index-Expanded (SciSearch®), Scopus

 

News & Social Media
View a selection of newsletters that were sent out recently by clicking on the links:
2020: Issue 1; Issue 2; Issue 3; Issue 4; Special Issue; Parkinson Prize 2020

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The Publisher

IOS Press publishes publishes around 90 journals and 70 books annually in a broad range of subject categories, primarily specializing in biomedical and life sciences (including neurosciences, medical informatics, cancer research, rehabilitation) and physical sciences (including computer sciences, artificial intelligence, engineering).

Headquartered in Amsterdam with satellite offices in the USA, Germany and China, IOS Press continues its rapid growth, embracing new technologies for the timely dissemination of information.

All journals are available in print and electronic format.

Letter from Stockholm: Dopamine: Carlsson’s Remarkable Chemical

The first speaker at the 18th International Congress of Parkinson’s Disease and Movement Disorders in Stockholm was Swedish Nobel laureate Arvid Carlsson. Carlsson, now in his 90s, eloquently told the story of his groundbreaking research in the 1950s that led to the dopamine theory of Parkinson’s disease. Carlsson recounted how he used the anti-psychotic medication reserpine to paralyze rabbits and how he then unfroze the animals with dopa.

Profile: Sara Riggare

In October 1984, a thirteen-year-old girl called Sara sat in a small village hall in northern Sweden enjoying a folk music concert. “Everyone was clapping their hands and stomping their feet,” Sara recalls, “and I wanted to do the same. I could clap my hands, but when I tried stomping my feet, I discovered I couldn’t. It was as if the signals couldn't go from my brain to my feet.” This is Sara’s earliest memory indicating that something was wrong.

Beyond the Snapshot

Every parkie is interested in knowing the answer to the question: “how am I doing?” We know we have a progressive disease and we really want some objective feedback on how our condition is different from say a year ago. What symptoms are worse, what’s better, what’s the same?

Profile: Tom Isaacs

In 1996, a 27-year-old London-based surveyor called Tom Isaacs was diagnosed with Parkinson's disease. Like others before him, he struggled to come to terms with his new identity. As he put it, “The truth was that I was now trapped inside a body that was now ageing at an alarming rate and was often incapable of responding to the demands put on it.”

The Patient Perspective: Joel Havemann

Every Parkinson’s patient is curious about what the future holds. One way to anticipate what’s coming is to learn from parkies further along in their disease. Unfortunately, it turns out that while many patient memoirs chronicle the early years of PD, there are very few accounts that document the long-term trajectory of the condition. An exception is Joel Havemann’s smart book, A Life Shaken.

Turning Failure into Success?

Every year, the NIH spends some $30 billion on biomedical research. The private sector – including the medical device industry, big pharma and the biotech sector –  chips in another $70 billion. What do we get for this investment? According to comedian Chris Rock, we don’t get many cures.

Interview: Caroline Tanner

Caroline (Carlie) Tanner had always planned to specialize in family medicine. But while a medical student in Chicago, she fell under the spell of neurologist Harold Klawans. Klawans – one of the first neurologist to use levodopa therapy with PD patients – convinced the young doctor that Parkinson’s was an exciting area of research and practice. Says Tanner, “The idea of being able to intervene with a transformative therapy like levodopa was very attractive, so after some soul-searching, I switched my concentration from family medicine to neurology.”

The L-dopa Conundrum

Few episodes in medical history are as dramatic as the “discovery” back in the 1960’s of L-dopa therapy. University of Rochester Medical Center’s Karl Kieburtz, an authority on the history of the drug, describes L-dopa as “one of the most potent therapies in all of neurology– indeed in all of medicine – think about it: to take someone who was essentially rigid like a stone…and enable them to get up and walk and function…it’s unbelievable.”

Now For The Bad News

The Holy Grail of PD research is to find a disease-modifying therapy. If one could deliver neurotrophic factors to the putamen, for example, and rescue ailing dopamine neurons, it might change the trajectory of the disease. Unfortunately, most recent efforts have ended in failure.

Interview: Roger Barker

Roger Barker says that he was inspired to become a clinician researcher after meeting the great neuroscientist David Marsden. As Barker puts it, “the minute I met David Marsden I wanted to be David Marsden, a person equally at home in the clinic and the laboratory”. When I visited the 51-year-old Parkinson’s and Huntington’s researcher during a recent visit to the UK, he seemed to be well on his way to accomplishing that goal.

Profile: Bastiaan Bloem

In the dramatic open to his 2011 TED talk, “From God to Guide,” neurologist Bastiaan “Bas” Bloem is lifted high above the stage by a crane to the sound of celestial music. Far below, a patient asks him for help. Bloem tersely tells the patient he has Parkinson’s disease and orders him to take carbidopa/levodopa three times a day. But the patient is not satisfied and complains in desperation, “Doctor you must take me seriously”.

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