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7 March 2017

Extended Use of MAO-B Inhibitors Slows Decline in Parkinson’s Disease Patients

There has long been interest in whether monoamine oxidase type B (MAO-B) inhibitors slow progression of Parkinson’s disease (PD) and improve long-term outcomes. They have shown neuroprotective effects in cell culture and animal studies of PD, but clinical trial results have been mixed and have failed to convincingly demonstrate disease modifying effects in people with PD. In a retrospective analysis by Hauser et al. in the Journal of Parkinson’s Disease, researchers looked at the results from a large study and found that participants who received an MAO-B inhibitor for a longer period of time experienced slower clinical decline.

13 February 2017

Altmetric Data Analysis Reveals How Parkinson’s Disease Research Affects the World

ÜberResearch and Altmetric, leading data and analytics companies serving scientific funders and research organizations, have published an analysis of Parkinson’s disease research papers with the highest Altmetric Attention Scores in the Journal of Parkinson’s Disease. The publication is the first in a series aimed at utilizing Altmetric data to provide a more nuanced understanding of how the announcements of new medical discoveries affect the wide-range of disease-specific stakeholders including researchers, funders, care providers, and patients.

15 November 2016

Hospital Admissions Rising for Elderly Patients with Parkinson’s Disease

Although treatment for Parkinson’s disease (PD) is significantly extending the lives of patients, these patients are now being admitted to hospitals at increasing rates. In a study reported in the Journal of Parkinson’s Disease, researchers in Ireland have found that the top five reasons for hospital admission of PD patients are urinary tract infections, pneumonia, lower respiratory tract infections, aspiration pneumonia and femur fracture. More troubling is the stark increase in PD patients requiring long-term nursing home care on discharge, with 27% of the over 65 group discharged to a nursing home compared to 12% admitted from a nursing home.

15 November 2016

Parkinson’s Disease Patients Benefit from Physical Activity

A comprehensive review published in the Journal of Parkinson’s Disease confirms that people living with Parkinson’s disease (PD) can benefit from being physically active, especially when it comes to improving gait and balance, and reducing risks of falls. It concludes that health professionals should be confident about prescribing physical activity to improve the health and quality of life of PD patients.

12 July 2016

Leukemia Drug Shows Early Promise for Treating Parkinson’s Disease and Dementia

Parkinson’s disease (PD) is the second most common neurodegenerative disorder that causes a range of motor and non-motor symptoms. During the course of the disease, dopamine (DA)-producing neurons are lost and bundles of proteins known as Lewy bodies (LBs) form in the brain. A study reported in the Journal of Parkinson’s Disease provided molecular evidence that the FDA-approved leukemia drug nilotinib may restore brain dopamine and reduce toxic proteins associated with LB formation in PD and dementia patients.

12 April 2016

Researchers Identify Tissue Biomarker for Dementia with Lewy Bodies and Parkinson’s Disease

Accurate diagnosis of Parkinson’s disease, and the related disease “dementia with Lewy bodies,” can be difficult in the early stages of both conditions. While brain biopsies can be more accurate, the risk of complications has been considered too high. New research published in the Journal of Parkinson’s Disease indicates that a biopsy of the submandibular gland can help identify the same pathology that is seen in the brain, providing some of the increased accuracy of brain biopsy, but not the increased risk.

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